I do not think we have an answer to that question one way or the other. Alterations in orgasm are linked with lower emotional and physical satisfaction, which might lead to stress for you and your partner. The .gov means its official. 2020 Jan;113(1):21-50. doi: 10.1016/j.fertnstert.2019.11.030. And youre competely right, they make it sound like youre doomed and you shouldnt try anything but wait for the Baylor study and fill out the surveyDo they really expect some magical cure to come out when Baylor releases or their survey has enough participants? There was this guy on propecia help called JustQuitDut who was a complete psycho, who thought that taking TRT with estrogen blockers would somehow solve it. Your doctor will ask you questions about your health and symptoms. Lol, now they banned me, just look at the reason: Dismissive of survey in first few posts; insistently advocated for dangerous and misleading article on PFS. Its on an auto refill and I get 90 day supplies sent to me in the mail. Im glad I did. I suspect that 2 mg would be adequate, but if my doc prescribes two 1mg pills per day, the insurance company wont pay for it because the 1mg pill is only approved for hair loss treatment. 2022 Oct 26;12(11):1567. doi: 10.3390/biom12111567. In addition, molecular mechanisms and/or genetic determinants behind such adverse effects have been poorly explored both in patients and animal models. WebIn addition to the sexual, mental and physical side effects, PK suffers from miscellaneous issues connected with PFS. Toxicol. To give you a bit of background, I'm a 34 year old male whose sexual function was utterly destroyed by finasteride/Propecia. This stuff WORKS. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. Accessibility Samplaski MK, et al. If so, how long have you been trying to conceive? "I had a case of PFS that was a severe as it gets. If your doctor suspects your dry orgasm is something other than retrograde ejaculation, you might need further tests or a referral to a specialist to find the cause. TRT so thats why I went down this rabbit hole. Adverse effects of common medications on male fertility. The supplement is making real changes in my body and mind, and it feels incredible. "Mayo," "Mayo Clinic," "MayoClinic.org," "Mayo Clinic Healthy Living," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation for Medical Education and Research. WebPost-finasteride syndrome (PFS) is a constellation of serious adverse side effects manifested in clinical symptoms that develop and persist in patients during and/or after discontinuing finasteride treatment in men with pattern hair loss (androgenetic alopecia) or Hcg I did 3000iu the first day then 250iu every other day for the four weeks. I suspect its because my E2 was so low already and that made it feel even lower (single digits if I recall correctly). Mesterolone (Proviron) is one of the best compounds that can be used for treating Post Finasteride Syndrome in my opinion. WebNeurogenesis was found to be reversed to normal 35 days after the last finasteride injection in male mice. Advertising revenue supports our not-for-profit mission. Brain fog. AR: androgen receptor; DHP: dihydroprogesterone; DHT: dihydrotestosterone; ER: estrogen receptor beta; PR: progesterone receptor; PROG: progesterone; T: testosterone; THP: tetrahydroprogesterone. It can prevent hair loss and decrease prostate enlargement, but not surprisingly, it can also suppress sexual function. Urology. What was the article? Your doctor might also do a physical exam that includes examining your penis, testicles and rectum. After a few days I starting liking women again and became sexually from frustrated. Crazy, but true! I read about the Post-Fin Syndrome and decided to quit (Almost) No erections, no libido. I feel deeply for all my balding brothers out there who are suffering from this poison. For details, see text. Clinical features reported in patients affected by post-finasteride syndrome. Post-finasteride syndrome (PFS) is defined as a syndrome with symptoms that can include erectile dysfunction (ED), decreased libido, fatigue, penile and scrotal atrophy and numbness, gynecomastia, muscle atrophy, anxiety, blunted affect, and emotional sensitivity in patients who have taken 5-reductase inhibitors such as finasteride or Here's some information to help you get ready for your appointment, and what to expect from your doctor. Waitttt wait wait. Post-finasteride syndrome (PFS) is a constellation of serious adverse side effects manifested in clinical symptoms that develop and persist in patients during and/or after discontinuing finasteride treatment in men with pattern hair loss (androgenetic alopecia) or benign prostatic hyperplasia. Fertility and Sterility. I'm not going to go into the entire history of what post finasteride syndrome is, and I assume many of you looking into buying Tribulus know exactly what it is. Adverse effects of 5-reductase inhibitors: What do we know, don't know, and need to know? Melcangi RC, Caruso D, Abbiati F, Giatti S, Calabrese D, Piazza F, Cavaletti G. J Sex Med. .ehsOqYO6dxn_Pf9Dzwu37{margin-top:0;overflow:visible}._2pFdCpgBihIaYh9DSMWBIu{height:24px}._2pFdCpgBihIaYh9DSMWBIu.uMPgOFYlCc5uvpa2Lbteu{border-radius:2px}._2pFdCpgBihIaYh9DSMWBIu.uMPgOFYlCc5uvpa2Lbteu:focus,._2pFdCpgBihIaYh9DSMWBIu.uMPgOFYlCc5uvpa2Lbteu:hover{background-color:var(--newRedditTheme-navIconFaded10);outline:none}._38GxRFSqSC-Z2VLi5Xzkjy{color:var(--newCommunityTheme-actionIcon)}._2DO72U0b_6CUw3msKGrnnT{border-top:none;color:var(--newCommunityTheme-metaText);cursor:pointer;padding:8px 16px 8px 8px;text-transform:none}._2DO72U0b_6CUw3msKGrnnT:hover{background-color:#0079d3;border:none;color:var(--newCommunityTheme-body);fill:var(--newCommunityTheme-body)} The guy who made this thread and gave his opinion was banned too. A mod answered and I answered the guy in a normal way, but they deleted my reply and blocked my account. Its H.C.G (HCG) dosed at 250IU Monday, Wednesday and Friday only. 2012;97:306. Am I at risk of complications from this condition? doi: 10.1210/jc.2016-2726. I am 100% reversed Keep in mind if I miss a dose or stop my protocol Pfs comes back full force. Speaking of which the proviron I ordered over a year ago randomly came in the mail the other day, haha. Do they benefit from people who have pfs so their foundation can continue and ask for more donations? Drugs generally won't help if retrograde ejaculation is due to surgery that causes permanent physical changes of your anatomy. Are there other possible causes for my symptoms or condition? -, Baig M.S., Kolasa-Wolosiuk A., Pilutin A., Safranow K., Baranowska-Bosiacka I., Kabat-Koperska J., Wiszniewska B. Finasteride-induced inhibition of 5alpha-reductase type 2 could lead to kidney damage-animal, experimental study. The dosage needs to be low and steady, do not increase or add a day thinking more is better. Your doctor will want to determine whether your dry orgasms are retrograde ejaculation or linked to another problem that may need further evaluation. Psychopharmacology (Berlin) 2014;231:35693580. A. Finasteride (sold as Proscar and generic brands) is prescribed for symptoms of an enlarged prostate; it's also used at a lower strength (under the name Propecia) for male pattern baldness. Do you have diabetes or any other chronic health problems? It can prevent hair loss and decrease prostate enlargement, but not surprisingly, it can also suppress sexual function. This is because (in the USA) it is only approved for BPH at 5mg and insurance companies will reject claims when it is prescibed at 1mg, which is the only other available dosage. Although these drugs are generally well tolerated, many reports described adverse effects in men during treatment, such as sexual dysfunction and mood alteration. Contemporary management of disorders of male orgasm and ejaculation. doi: 10.1177/0960327119842195. Of course I said this in a respectable manner Result: post deleted and banned. Int. https://old.reddit.com/r/PostFinSyndrome/comments/ogcsjc/i_recovered_from_pfs_it_is_possible/. 2016;101:46694680. Clipboard, Search History, and several other advanced features are temporarily unavailable. Epub 2022 Feb 3. Please visit the wiki for published research, symptoms, and more. WebPost-finasteride syndrome occurs in men whove taken finasteride to treat hair loss or enlarged prostates. Incredible! I didnt feel any improvement and felt worse during that period but after that period I healed which is very weird. there are many options including peptides, and HCG as well as clomid/arimidex. If your doctor thinks drugs you are taking might be affecting your ability to ejaculate normally, he or she might have you stop taking them for a period of time. https://old.reddit.com/r/steroids/comments/m5m7o9/help_steroids_for_pssd/gr0uhqj/. What the hell? Ketamine for treatment-resistant depression: When and where is it safe? Metabolism of progesterone and testosterone into 5alpha-reduced metabolites and their mechanisms of action: effects of finasteride and dutasteride. ._3bX7W3J0lU78fp7cayvNxx{max-width:208px;text-align:center} Are there any brochures or other printed material that I can take home with me? All rights reserved. To give you a bit of background, I'm a 34 year old male whose sexual function was utterly destroyed by finasteride/Propecia. 2016;93:9. Therefore, I cut the pills in half (2.5mg) and toss the other half. Can sperm be retrieved from my bladder and used for fertility treatment? Arimidex 0.5mg-3mg a day as needed (keep this dose around 1mg a day, too high and you will have low estrogen, torem may prevent you from needing it, everyone is different, I may not need it anymore, I recommend taking it only as needed, Torem 60mg a day (new drug instead of hcg that is an estrogen blocker and being tested as a treatment for androgen insensitivity), DHEA 50mg 1-2X a day (sometimes 2 X if I feel I need a mood boost), Calcium D Glucarate 1500mg (as many times a day as I remember, about 3X is good), Reservatrol (whatever dose a day, its an extra), https://forum.propeciahelp.com/t/final-protocol-100-pfs-reversal-with-dht-therapy-lastpost/7845/2147. 2022 Oct;11(10):1452-1457. doi: 10.21037/tau-22-92. https://www.jasonemermd.com/cosmetic-dermatology/regenerative-medicine/hormonal-optimization/. They have some pretty smart people and are open to trying about anything, and isnt as negative as the other forum. I tried proviron for a short time but it made me feel worse. https://old.reddit.com/r/FinasterideSyndrome/comments/psjeuu/could_trying_finasteride_for_1_month_be_harmfull/he38hlf/. Most men eventually develop some type of prostate problem, and when they do there are usually no easy solutions. 2015;104:107. Therefore, understand that I can't promise this will work for youbut for me? Ive personally recovered from pfs but what worked for me may not work for you as each of our bodies react differently to this condition depending on individuals factors. Fertility and Sterility. | How To Diagnose And Reverse It. I have had a recent report of a man who went on Human Growth Hormone and reversed his post finasteride syndrome sexual dysfunction. Can electrical brain stimulation boost attention, memory, and more? Not orgasm strength and sperm levels have returned, just waiting on my brain to communicate with my penis when its time for sexual intercourse. The drug has a very short half life in the bode, but the $1,000,000 question is whether there a a long-term alteration in DHT production and/or effectiveness. Some people had to use anabolic steroids because herbs weren't strong enough. Studies show it can help slow or reverse the process of hair loss. I recovered and I hope all of you suffering from PFS recover too. Now I can happily say that I no longer have any problem, strong erection all day and all night. 2016 Sep;13(9):1297-1310. doi: 10.1016/j.jsxm.2016.07.006. Especially at an Early Age Like in Their 20s? I took a prescription-strength anti-estrogen, Tamoxifen 10mg, twice a day: one at around 3pm and another one together with my test booster before bedtime. A community dedicated to people suffering long term effects after taking 5-ar inhibitors such as Propecia/Finasteride, or for people who wish to know more about the constellation of symptoms commonly known as Post Finasteride Syndrome. Accessed Sept. 15, 2016. (photo). Check his posts and look at the reasons. That is 250IU, not a typo so youll mix your 5000iu HCG with 5CC water and take 1/4 CC intramuscular three times a week using an insulin needle Have you heard about it? Finasteride blocks the metabolism of testosterone. Very controversial topic in this forum. Or at the very least allow people to post ideas. Exp. Will medications help me ejaculate normally? Public Health. This is to be expected because you are messing with a hormone (DHT) that is very important for sexual function. For what it's worth, here's a couple similar success stories involving numbness, but from PSSD instead of PFS: Testosterone along with initial estrogen management , completely cured my pssd, everything from numbness, to hard on quality , no morning wood, to actually having sexual desires again. Their attitude is 100% there is no cure, it wont get better, nothing works, anything that does work doesnt work long term, and thats just how it is. Treatment for Post Finasteride Syndrome There is no known treatment of PFS. Even Viagra wouldnt get me hard. After stopping 7 weeks later (when I ran out of my proviron), things felt off for a few weeks but then after around two months I got back to my pre-PFS state. And quite frankly, if you think big pharma doesn't have millions and millions of dollars wrapped up in trying to cover up just how severely finasteride has destroyed mens' lives, you're fooling yourself. This can be caused by damage to the prostate or semen-producing glands as a result of surgery or radiation treatment for cancer in the pelvic area. Press question mark to learn the rest of the keyboard shortcuts. Note that prior to this protocol I tried injectable Test enanthate, Masteron, proviron and hcg which made my condition even worse. Retrograde ejaculation typically doesn't require treatment unless it interferes with fertility. The steroidogenic inhibitor finasteride reverses pramipexole-induced alterations in probability discounting. Li X, Guo Y, Lu Y, Li H, Yan S, Li H, Li Y. Transl Androl Urol. -. I'm Just 18 and I'm Losing my Hair. Q. I have heard that finasteride, which I take for my prostate problem, can cause permanent impotence. The only thing that makes sense is to push your androgen receptors and epigenetics the opposite way fin did. Authors received funding from the Post-Finasteride Foundation in order to study PFS symptomatology of patients and in experimental models. Pumpkin Seed Oil-Loaded Niosomes for Topical Application: 5-Reductase Inhibitory, Anti-Inflammatory, and In Vivo Anti-Hair Loss Effects. Its like they want to hide possible solutions. The common denominator in how I feel is Tribulus, period, end of sentence. This condition, termed post-finasteride syndrome (PFS) is characterized by sexual side effects (i.e., low libido, erectile dysfunction, decreased arousal and difficulty in achieving orgasm), depression, anxiety and cognitive complaints that are still present despite drug withdrawal. Plus, get a FREE copy of the Best Diets for Cognitive Fitness. In: Ferri's Clinical Advisor 2022. Disorders of male orgasm and ejaculation. My life is finally back. What is likely causing my symptoms or condition? With prostate cancer deaths overtaking that of breast cancer, it is important to know the side effects of finasteride. 2015 Sep;16(3):177-98. doi: 10.1007/s11154-015-9319-y. moreplatesmoredates.com. " On PFS forums, peoples dicks got 1 inch bigger when erect, here and there, they sometimes felt sexual attraction towards women. I am not aware or scientific evidence that back this up at this time. Diagnosing and Reversing It", Is Post Finasteride Syndrome Real? Finasteride (Propecia) is a medication that can help treat MPB by lowering levels of DHT. Answer: Hormonal optimization while on finesteride there are many options including peptides, and HCG as well as clomid/arimidex. Disclaimer. Do you have cloudy urine after an orgasm? Now and for the past six months, I feel great, my libido is great, mental issues are gone, ED is gone. https://forum.propeciahelp.com/t/cured-after-11-years/42363. Minoxidil is FDA approved for genetic hair loss - it does not help other conditions quite so much. J. Clin. Liu L, Zhao S, Li F, Li E, Kang R, Luo L, Luo J, Wan S, Zhao Z. J Sex Med. I cannot say enough about this. Accessed Oct. 28, 2021. 5alpha-reductase; Androgenetic alopecia; Depression; Finasteride; Neuroactive steroids; Sexual dysfunction. I had all the classic symptoms. Thats probably the worst part if you only read that forum youre pretty much going to feel hopeless. Urologic Clinics of North America. For each day that goes by, I get a day of surplus inventory. This is not proof that finasteride is to blame, since a variety of medical conditions and other prescription drugs could explain the sexual symptoms. Like I said, almost starting to believe they want people to keep having pfs so they can benefit in some form or another. I'll be interested to see if this has any effects on my weight loss endeavors. 2013 Oct;10(10):2598-603. doi: 10.1111/jsm.12269. Yeah the joe_kool guy or whatever his name is had really good luck with TRT, he is honestly the reason I went down this road. And posted the article and some cliffs about his solution. Depending on the likely cause of your dry orgasms and whether you need evaluation and treatment to help you get your female partner pregnant, you might need to see a urinary and reproductive specialist (urologist). You can't get worse than living with no dick dude. | How To Diagnose And Reverse It. Merck developed finasteride in the 1980s. I also started a thread but they merged it. Essentially I took testosterone exogenously And I took hcg afterwards, https://old.reddit.com/r/PSSD/comments/7lfc1e/how_i_fixed_my_pssd/. Stopping finasteride treatment can cause post-finasteride syndrome. This area was the most recovery and reversal of symptoms. Will my partner and I likely need to use assisted reproductive technology, such as intrauterine insemination, to achieve pregnancy? The presence of side effects during pharmacological treatment is unfortunately a quite common problem. National Library of Medicine No energy. Minoxidil takes 4-6 months before an individual should assess whether or not it helps. At some point you just cant store it all or want to use old drug. Amedical opinion on this procedure would be important, because we do not have scientific evidence about HCG and PFS, but it would already be a start. If youre experiencing a medical issue, please contact a healthcare professional or dial 911 immediately. I could be wrong but none of them seem to have anhedonia or genital numbness or fatigue or insomnia or anything, just libido and ED issues. I read the thing on Healthline where it says it doesn't raise testosterone in humans. Around 8 months and i was pretty much recovered. These include: Prostate pain Persistent fatigue, exhaustion Stomach pains and digestive problems Constipation Blurry vision Propecia is the Biggest Regret of my Life Taking Propecia is the biggest regret of my life, PK said. Metabolism of progesterone and testosterone, Metabolism of progesterone and testosterone into 5alpha-reduced metabolites and their mechanisms of action:, Clinical features reported in patients affected by post-finasteride syndrome. breast enlargement. I have not made any drastic life changes since beginning this. 2008;35:211. More than a primer on prostate conditions, this Special Health Report, the Annual Report on Prostate Diseases, includes roundtable discussions with experts at the forefront of prostate research, interviews with men about their treatment decisions, and the latest thinking on complementary therapies. Mod also deleted my second post where I said he indeed has affiliate links to herbs but doesnt even believe that will be enough for pfs patients, the real cure is proviron. The drug reduces a testosterone-related hormone in certain tissues, including skin and the prostate gland. ._3Z6MIaeww5ZxzFqWHAEUxa{margin-top:8px}._3Z6MIaeww5ZxzFqWHAEUxa ._3EpRuHW1VpLFcj-lugsvP_{color:inherit}._3Z6MIaeww5ZxzFqWHAEUxa svg._31U86fGhtxsxdGmOUf3KOM{color:inherit;fill:inherit;padding-right:8px}._3Z6MIaeww5ZxzFqWHAEUxa ._2mk9m3mkUAeEGtGQLNCVsJ{font-family:Noto Sans,Arial,sans-serif;font-size:14px;font-weight:400;line-height:18px;color:inherit} If a high volume of sperm is found in your urine, you have retrograde ejaculation. Crazy. Indeed, some national agencies (e.g., Swedish Medical Products Agency, the Medicines and Healthcare Products Regulatory Agency of UK and the U.S. Food and Drug Administration) required to include multiple persistent side effects within the finasteride labels. Examples include bladder neck surgery and transurethral resection of the prostate. I took intramuscular injections of HCG every 3 a 5 days 1500 to 3000 ui by injections for 1 months only, and after that some Clomid for 10 days 2 pills by day It helped relaunch the natural testorene levels so my libido increased again i am now totally satisfied with my health :slight_smile: https://forum.propeciahelp.com/t/i-believe-i-have-been-cured-by-accident/4054, Yes After nearly 4 years of suffering, I have finally & fully recovered from Post Finasteride Syndrome, All my symptoms have subsided and improved with this method which takes a while but I am fully functional. Im talking about the physical inability to have erections and sex drive". Pharmacological Management of Pattern Hair Loss. No content on this site, regardless of date, should ever be used as a substitute for direct medical advice from your doctor or other qualified clinician. Firstly, hair loss doesn't just affect older people. This content does not have an English version. Ive seen this several times over there. I'm not a gym rat, I just make sure to walk 3-5 miles a day and do my best to watch what I eat (that's always been the case.) WebPost finasteride syndrome is real. Hello, some finasteride users have reported the reversal of post-finasteride syndrome using HCG as therapy. This is a summary of the protocol which I followed for 6 months which eventually cured me. Its less than ideal though when trying to help people and you get banned for it, That forum is a farce, it seems their solution is to just wait, could help for some but others are waiting for years without improving. This content does not have an Arabic version. I dont really understand why theyre like that. After I got PFS my libido died, I stopped liking women, my brain wouldn't work, and my personality changed to a 90 old man. Next steps is likely getting a Hey there, Ive read theres on guy there who recoverd recently from HCG, very interesting. more https://www.jasonemermd.com/cosmetic-dermatology/regenerative-medicine/hormonal Feeling low-grade depression constantly. Midodrine, a medicine that constricts blood vessels, Chlorpheniramine and brompheniramine, antihistamines that help relieve allergies, Ephedrine, pseudoephedrine and phenylephrine, medicines that help relieve symptoms of the common cold. PMC Of course there are some people with severe pfs but even then just wait is shit advice. I understand theyre trying to cover their ass but its the users responsibility if he wants to try it or not so the forum is not liable at all. ._9ZuQyDXhFth1qKJF4KNm8{padding:12px 12px 40px}._2iNJX36LR2tMHx_unzEkVM,._1JmnMJclrTwTPpAip5U_Hm{font-size:16px;font-weight:500;line-height:20px;color:var(--newCommunityTheme-bodyText);margin-bottom:40px;padding-top:4px;text-align:left;margin-right:28px}._2iNJX36LR2tMHx_unzEkVM{-ms-flex-align:center;align-items:center;display:-ms-flexbox;display:flex}._2iNJX36LR2tMHx_unzEkVM ._24r4TaTKqNLBGA3VgswFrN{margin-left:6px}._306gA2lxjCHX44ssikUp3O{margin-bottom:32px}._1Omf6afKRpv3RKNCWjIyJ4{font-size:18px;font-weight:500;line-height:22px;border-bottom:2px solid var(--newCommunityTheme-line);color:var(--newCommunityTheme-bodyText);margin-bottom:8px;padding-bottom:8px}._2Ss7VGMX-UPKt9NhFRtgTz{margin-bottom:24px}._3vWu4F9B4X4Yc-Gm86-FMP{border-bottom:1px solid 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finasteride is an important medication for older guys on TRT that are experiencing BPH. ._2FKpII1jz0h6xCAw1kQAvS{background-color:#fff;box-shadow:0 0 0 1px rgba(0,0,0,.1),0 2px 3px 0 rgba(0,0,0,.2);transition:left .15s linear;border-radius:57%;width:57%}._2FKpII1jz0h6xCAw1kQAvS:after{content:"";padding-top:100%;display:block}._2e2g485kpErHhJQUiyvvC2{-ms-flex-align:center;align-items:center;display:-ms-flexbox;display:flex;-ms-flex-pack:start;justify-content:flex-start;background-color:var(--newCommunityTheme-navIconFaded10);border:2px solid transparent;border-radius:100px;cursor:pointer;position:relative;width:35px;transition:border-color .15s linear,background-color .15s 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